Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR

Research output: Contribution to journalReviewResearchpeer-review

Riki Ogasawara, Thomas Elbenhardt Jensen, Craig A Goodman, Troy A Hornberger

The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.

Summary: This review examines whether both rapamycin-sensitive, and rapamycin-insensitive, components of mTOR signaling contribute to the hypertrophic effects of resistance exercise.

Original languageEnglish
JournalExercise and Sport Sciences Reviews
Volume47
Issue number3
Pages (from-to)188-194
Number of pages7
ISSN0091-6331
DOIs
Publication statusPublished - 2019

    Research areas

  • The Faculty of Science - Exercise, Hypertrophy, Protein synthesis, mTOR, mTORC1, mTORC2, Rapamycin

ID: 214870916