Repolarization Effects of sertindole manifest as T-wave flatness on the ECG

Research output: Contribution to journalConference articleResearchpeer-review

Tanveer A. Bhuiyan, Claus Graff, Jørgen K. Kanters, Jimmi Nielsen, Johannes J. Struijk

Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.

Original languageEnglish
Article number7043059
JournalComputing in Cardiology
Volume41
Issue numberJanuary
Pages (from-to)381-384
Number of pages4
ISSN2325-8861
Publication statusPublished - 1 Jan 2014
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: 7 Sep 201410 Sep 2014

Conference

Conference41st Computing in Cardiology Conference, CinC 2014
CountryUnited States
CityCambridge
Period07/09/201410/09/2014
Sponsoret al., IEEE/EMBS, Massachusetts Institute of Technology (MiT), Mortara, Philips, PhysioNet

ID: 204298963