Repaglinide at a cellular level

Research output: Contribution to journalJournal articleResearchpeer-review

M Krogsgaard Thomsen, K Bokvist, M Høy, K Buschard, Jens Juul Holst, P Lindström, J Gromada

To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.

Original languageEnglish
JournalDiabetes, nutrition & metabolism
Volume15
Issue number6 Suppl
Pages (from-to)15-8
Number of pages4
ISSN0394-3402
Publication statusPublished - Dec 2002

    Research areas

  • Animals, Carbamates, Cyclohexanes, Electrophysiology, Exocytosis, Hypoglycemic Agents, Islets of Langerhans, Membrane Potentials, Phenylalanine, Piperidines, Postprandial Period, Potassium Channels, Rats

ID: 132056158