Radioiodine therapy in hyperthyroid disease: poorer outcome in patients with high 24 hours radioiodine uptake.

Research output: Contribution to journalJournal articleResearchpeer-review

Ulrik Sloth Kristoffersen, Birger Hesse, Ase Krogh Rasmussen, Andreas Kjaer

PURPOSE: To evaluate the importance of 24 h radioiodine uptake (24 h RIU) for the outcome of radioiodine treatment of hyperthyroidism. METHODS: Retrospective analysis of 72 patients who underwent radioiodine treatment for toxic goiter at our outpatient clinic [29 diffuse goiters (DG), 30 toxic multinodular goiters (TMG) and 13 toxic adenomas (TA)]. Thyroid status was determined by TSH, fT3 and fT4 levels, and outcome was rendered successful when hyperthyroidism was absent. Relation between low 24 h RIU (below median) or high 24 h RIU (above or equal to median) and outcome was evaluated. RESULTS: Of patients with DG and low 24 h RIU, 15% remained hyperthyroid, as opposed to 56% of patients with DG and high 24 h RIU (P<0.05). Of patients with TMG and low 24 h RIU, none remained hyperthyroid, as opposed to 44% of patients with TMG and high 24 h RIU (P<0.01). Of patients with TA and low 24 h RIU, none remained hyperthyroid, as opposed to 43% of patients with TA and high 24 h RIU (NS, P = 0.19). CONCLUSION: In patients with hyperthyroid disease treated with radioiodine the outcome is poorer for patients with high 24 h RIU compared with low 24 h RIU measured prior to treatment when the radioiodine dose is calculated on the basis of 24 h RIU.
Original languageEnglish
JournalClinical Physiology and Functional Imaging
Issue number3
Pages (from-to)167-70
Number of pages3
Publication statusPublished - 2006

Bibliographical note

Keywords: Dose-Response Relationship, Radiation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperthyroidism; Iodine Radioisotopes; Male; Middle Aged; Retrospective Studies; Thyroid Function Tests; Thyrotropin; Thyroxine; Treatment Outcome; Triiodothyronine

ID: 8465197