Predictors of accelerated FEV1 decline in adults with airflow limitation: Findings from the Health2006 cohort

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Camilla Boslev Baarnes, Betina H. Thuesen, Allan Linneberg, Amalie S. Ustrup, Signe Knag Pedersen, Charlotte Suppli Ulrik

To investigate predictors of accelerated decline in forced expiratory volume in 1 s (FEV1) in individuals with preexisting airflow limitation (AL). Participants in the Health2006 baseline study aged ≥ 35 with FEV1/ forced vital capacity (FVC) < lower limit of normal (LLN) were invited for a 10-year follow-up. At both examinations, data were obtained on demographics, spirometry, fitness level, allergy, and exhaled nitric oxide. We used multiple regression modeling to predict the annual decline in FEV1, reported as regression coefficients (R) and 95% confidence intervals (CIs). A total of 123 (43% of those invited) participated in the follow-up examination, where more had exercise-induced dyspnea but fewer had asthma symptoms. Being female (R = −29.8 ml, CI: −39.7 to −19.8), diagnosed with asthma (R = −13.7, CI: −20.4 to −7.0) or atopic dermatitis (R = −29.0, CI: −39.7 to −18.4), and having current asthma symptoms or nightly respiratory symptoms (R = −22.1, CI: −31.9 to −12.4 and R = −14.3, CI: −19.9 to −8.7, respectively) were significantly associated with a steeper decline in FEV1. Although to a smaller extent, a steeper decline was also predicted by age, baseline FEV1, waist/hip-ratio, and number of pack-years smoked. In individuals with preexisting AL, being female and having ever or current respiratory symptoms were associated with an accelerated annual decline in FEV1.

Original languageEnglish
Article number1479973119838278
JournalChronic Respiratory Disease
Volume16
Number of pages11
ISSN1479-9723
DOIs
Publication statusE-pub ahead of print - 2019

    Research areas

  • Airflow limitation, asthma, chronic obstructive pulmonary disease, lung function decline, respiratory symptoms

ID: 224024691