Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report

Research output: Contribution to journalJournal articleResearchpeer-review

Carsten Dirksen, Dorte L Hansen, Sten Madsbad, Lisbeth E Hvolris, Lars S Naver, Jens Juul Holst, Dorte Worm

OBJECTIVE: To examine after gastric bypass the effect of peroral versus gastroduodenal feeding on glucose metabolism.

RESEARCH DESIGN AND METHODS: A type 2 diabetic patient was examined on 2 consecutive days 5 weeks after gastric bypass. A standard liquid meal was given on the first day into the bypassed gastric remnant and on the second day perorally. Plasma glucose, insulin, C-peptide, glucagon, incretin hormones, peptide YY, and free fatty acids were measured.

RESULTS: Peroral feeding reduced 2-h postprandial plasma glucose (7.8 vs. 11.1 mmol/l) and incremental area under the glucose curve (iAUC) (0.33 vs. 0.49 mmol . l(-1) . min(-1)) compared with gastroduodenal feeding. beta-Cell function (iAUC(Cpeptide/Glu)) was more than twofold improved during peroral feeding, and the glucagon-like peptide (GLP)-1 response increased nearly fivefold.

CONCLUSIONS: Improvement in postprandial glucose metabolism after gastric bypass is an immediate and direct consequence of the gastrointestinal rearrangement, associated with exaggerated GLP-1 release and independent of changes in insulin sensitivity, weight loss, and caloric restriction.

Original languageEnglish
JournalDiabetes Care
Volume33
Issue number2
Pages (from-to)375-7
Number of pages3
DOIs
Publication statusPublished - Feb 2010

    Research areas

  • Area Under Curve, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Enteral Nutrition, Fatty Acids, Nonesterified, Gastric Bypass, Glucagon, Glucagon-Like Peptide 1, Humans, Incretins, Male, Middle Aged, Obesity, Morbid, Peptide YY, Postoperative Period, Postprandial Period

ID: 132048092