Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. / Darusman, Huda S; Pandelaki, Jacub; Mulyadi, Rahmad; Sajuthi, Dondin; Putri, Indah A; Kalliokoski, Otto H; Call, Josep; Abelson, Klas S P; Schapiro, Steve; Gjedde, Albert; Hau, Jann.

In: In Vivo, Vol. 28, No. 2, 19.03.2014, p. 173-84.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Darusman, HS, Pandelaki, J, Mulyadi, R, Sajuthi, D, Putri, IA, Kalliokoski, OH, Call, J, Abelson, KSP, Schapiro, S, Gjedde, A & Hau, J 2014, 'Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid', In Vivo, vol. 28, no. 2, pp. 173-84.

APA

Darusman, H. S., Pandelaki, J., Mulyadi, R., Sajuthi, D., Putri, I. A., Kalliokoski, O. H., ... Hau, J. (2014). Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. In Vivo, 28(2), 173-84.

Vancouver

Darusman HS, Pandelaki J, Mulyadi R, Sajuthi D, Putri IA, Kalliokoski OH et al. Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. In Vivo. 2014 Mar 19;28(2):173-84.

Author

Darusman, Huda S ; Pandelaki, Jacub ; Mulyadi, Rahmad ; Sajuthi, Dondin ; Putri, Indah A ; Kalliokoski, Otto H ; Call, Josep ; Abelson, Klas S P ; Schapiro, Steve ; Gjedde, Albert ; Hau, Jann. / Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. In: In Vivo. 2014 ; Vol. 28, No. 2. pp. 173-84.

Bibtex

@article{83b738b10cc14afa90c2df8a846971de,
title = "Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid",
abstract = "BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.",
author = "Darusman, {Huda S} and Jacub Pandelaki and Rahmad Mulyadi and Dondin Sajuthi and Putri, {Indah A} and Kalliokoski, {Otto H} and Josep Call and Abelson, {Klas S P} and Steve Schapiro and Albert Gjedde and Jann Hau",
year = "2014",
month = "3",
day = "19",
language = "English",
volume = "28",
pages = "173--84",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "2",

}

RIS

TY - JOUR

T1 - Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

AU - Darusman, Huda S

AU - Pandelaki, Jacub

AU - Mulyadi, Rahmad

AU - Sajuthi, Dondin

AU - Putri, Indah A

AU - Kalliokoski, Otto H

AU - Call, Josep

AU - Abelson, Klas S P

AU - Schapiro, Steve

AU - Gjedde, Albert

AU - Hau, Jann

PY - 2014/3/19

Y1 - 2014/3/19

N2 - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

AB - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

M3 - Journal article

VL - 28

SP - 173

EP - 184

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 2

ER -

ID: 126435919