Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result

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Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result. / Holmkvist, J; Anthonsen, S; Wegner, L; Andersen, G; Jørgensen, T; Borch-Johnsen, K; Sandbaek, A; Lauritzen, T; Pedersen, Oluf; Hansen, T.

In: Diabetologia, Vol. 51, No. 4, 2008, p. 609-14.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Holmkvist, J, Anthonsen, S, Wegner, L, Andersen, G, Jørgensen, T, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Pedersen, O & Hansen, T 2008, 'Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result', Diabetologia, vol. 51, no. 4, pp. 609-14. https://doi.org/10.1007/s00125-008-0925-z

APA

Holmkvist, J., Anthonsen, S., Wegner, L., Andersen, G., Jørgensen, T., Borch-Johnsen, K., ... Hansen, T. (2008). Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result. Diabetologia, 51(4), 609-14. https://doi.org/10.1007/s00125-008-0925-z

Vancouver

Holmkvist J, Anthonsen S, Wegner L, Andersen G, Jørgensen T, Borch-Johnsen K et al. Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result. Diabetologia. 2008;51(4):609-14. https://doi.org/10.1007/s00125-008-0925-z

Author

Holmkvist, J ; Anthonsen, S ; Wegner, L ; Andersen, G ; Jørgensen, T ; Borch-Johnsen, K ; Sandbaek, A ; Lauritzen, T ; Pedersen, Oluf ; Hansen, T. / Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result. In: Diabetologia. 2008 ; Vol. 51, No. 4. pp. 609-14.

Bibtex

@article{77585150eede11ddbf70000ea68e967b,
title = "Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result",
abstract = "AIMS/HYPOTHESIS: A genome-wide association study recently identified an association between common variants, rs1535435 and rs9494266, in the AHI1 gene and type 2 diabetes. The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals. METHODS: The previously associated polymorphisms were genotyped in the population-based Inter99 cohort (n=6162), the Danish ADDITION study (n=8428), a population-based sample of young healthy participants (n=377) and in additional type 2 diabetes (n=2107) and glucose-tolerant participants (n=483) using Taqman allelic discrimination. The case-control study involved 4,104 type 2 diabetic patients and 5,050 glucose-tolerant control participants. Type 2 diabetes-related traits were investigated in 17,521 individuals. RESULTS: rs1535435 and rs9494266 were not associated with type 2 diabetes. Odds ratios (OR) were OR(add) 1.0 (95{\%} C.I. 0.9-1.2; p(add)=0.7) and OR(add) 1.1 (0.9-1.2; p(add)=0.4), respectively, a finding supported by meta-analyses: OR(add) 1.0 (0.9-1.1; p(add)=0.6) and OR(add) 1.0 (0.9-1.1; p(add)=0.6), respectively. Neither rs1535435 nor rs9494266 were consistently associated with any of the tested type 2 diabetes-related metabolic traits. CONCLUSIONS/INTERPRETATION: Data from large samples of Danish individuals do not support a role for AHI1 rs1535435 nor rs9494266 as major type 2 diabetes variants. This study highlights the importance of independent and well-powered replication studies of the recent genome-wide association scans before a locus is robustly validated as being associated with type 2 diabetes.",
author = "J Holmkvist and S Anthonsen and L Wegner and G Andersen and T J{\o}rgensen and K Borch-Johnsen and A Sandbaek and T Lauritzen and Oluf Pedersen and T Hansen",
note = "Keywords: Adaptor Proteins, Signal Transducing; Body Mass Index; DNA Replication; Denmark; Diabetes Mellitus, Type 2; Discriminant Analysis; Genome, Human; Genotype; Heterozygote Detection; Humans; Phenotype",
year = "2008",
doi = "10.1007/s00125-008-0925-z",
language = "English",
volume = "51",
pages = "609--14",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result

AU - Holmkvist, J

AU - Anthonsen, S

AU - Wegner, L

AU - Andersen, G

AU - Jørgensen, T

AU - Borch-Johnsen, K

AU - Sandbaek, A

AU - Lauritzen, T

AU - Pedersen, Oluf

AU - Hansen, T

N1 - Keywords: Adaptor Proteins, Signal Transducing; Body Mass Index; DNA Replication; Denmark; Diabetes Mellitus, Type 2; Discriminant Analysis; Genome, Human; Genotype; Heterozygote Detection; Humans; Phenotype

PY - 2008

Y1 - 2008

N2 - AIMS/HYPOTHESIS: A genome-wide association study recently identified an association between common variants, rs1535435 and rs9494266, in the AHI1 gene and type 2 diabetes. The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals. METHODS: The previously associated polymorphisms were genotyped in the population-based Inter99 cohort (n=6162), the Danish ADDITION study (n=8428), a population-based sample of young healthy participants (n=377) and in additional type 2 diabetes (n=2107) and glucose-tolerant participants (n=483) using Taqman allelic discrimination. The case-control study involved 4,104 type 2 diabetic patients and 5,050 glucose-tolerant control participants. Type 2 diabetes-related traits were investigated in 17,521 individuals. RESULTS: rs1535435 and rs9494266 were not associated with type 2 diabetes. Odds ratios (OR) were OR(add) 1.0 (95% C.I. 0.9-1.2; p(add)=0.7) and OR(add) 1.1 (0.9-1.2; p(add)=0.4), respectively, a finding supported by meta-analyses: OR(add) 1.0 (0.9-1.1; p(add)=0.6) and OR(add) 1.0 (0.9-1.1; p(add)=0.6), respectively. Neither rs1535435 nor rs9494266 were consistently associated with any of the tested type 2 diabetes-related metabolic traits. CONCLUSIONS/INTERPRETATION: Data from large samples of Danish individuals do not support a role for AHI1 rs1535435 nor rs9494266 as major type 2 diabetes variants. This study highlights the importance of independent and well-powered replication studies of the recent genome-wide association scans before a locus is robustly validated as being associated with type 2 diabetes.

AB - AIMS/HYPOTHESIS: A genome-wide association study recently identified an association between common variants, rs1535435 and rs9494266, in the AHI1 gene and type 2 diabetes. The aim of the present study was to investigate the putative association between these polymorphisms and type 2 diabetes or type 2 diabetes-related metabolic traits in Danish individuals. METHODS: The previously associated polymorphisms were genotyped in the population-based Inter99 cohort (n=6162), the Danish ADDITION study (n=8428), a population-based sample of young healthy participants (n=377) and in additional type 2 diabetes (n=2107) and glucose-tolerant participants (n=483) using Taqman allelic discrimination. The case-control study involved 4,104 type 2 diabetic patients and 5,050 glucose-tolerant control participants. Type 2 diabetes-related traits were investigated in 17,521 individuals. RESULTS: rs1535435 and rs9494266 were not associated with type 2 diabetes. Odds ratios (OR) were OR(add) 1.0 (95% C.I. 0.9-1.2; p(add)=0.7) and OR(add) 1.1 (0.9-1.2; p(add)=0.4), respectively, a finding supported by meta-analyses: OR(add) 1.0 (0.9-1.1; p(add)=0.6) and OR(add) 1.0 (0.9-1.1; p(add)=0.6), respectively. Neither rs1535435 nor rs9494266 were consistently associated with any of the tested type 2 diabetes-related metabolic traits. CONCLUSIONS/INTERPRETATION: Data from large samples of Danish individuals do not support a role for AHI1 rs1535435 nor rs9494266 as major type 2 diabetes variants. This study highlights the importance of independent and well-powered replication studies of the recent genome-wide association scans before a locus is robustly validated as being associated with type 2 diabetes.

U2 - 10.1007/s00125-008-0925-z

DO - 10.1007/s00125-008-0925-z

M3 - Journal article

VL - 51

SP - 609

EP - 614

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -

ID: 10027083