PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

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Gitte Andersen, Lise Wegner, Dorit Packert Jensen, Charlotte Glümer, Lise Tarnow, Thomas Drivsholm, Pernille Poulsen, Sara Kristine Hansen, Eva-Maria Damsgaard Nielsen, Jakob Ek, Peter Mouritzen, Allan Vaag, Hans-Henrik Parving, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen, Oluf Pedersen

PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.
Original languageEnglish
JournalHypertension
Volume45
Issue number4
Pages (from-to)565-70
Number of pages6
DOIs
Publication statusPublished - 1 Apr 2005

    Research areas

  • Adult, Aged, Blood Pressure, Denmark, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Glycine, Heat-Shock Proteins, Humans, Hypertension, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Reverse Transcriptase Polymerase Chain Reaction, Risk, Serine, Sex Characteristics, Transcription Factors

ID: 33030458