Peptide-enhanced oral delivery of therapeutic peptides and proteins

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Peptide-enhanced oral delivery of therapeutic peptides and proteins. / Kristensen, Mie; Foged, Camilla; Berthelsen, Jens; Nielsen, Hanne Mørck.

In: Journal of Drug Delivery Science and Technology, Vol. 23, No. 4, 2013, p. 365-373.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Kristensen, M, Foged, C, Berthelsen, J & Nielsen, HM 2013, 'Peptide-enhanced oral delivery of therapeutic peptides and proteins', Journal of Drug Delivery Science and Technology, vol. 23, no. 4, pp. 365-373.

APA

Kristensen, M., Foged, C., Berthelsen, J., & Nielsen, H. M. (2013). Peptide-enhanced oral delivery of therapeutic peptides and proteins. Journal of Drug Delivery Science and Technology, 23(4), 365-373.

Vancouver

Kristensen M, Foged C, Berthelsen J, Nielsen HM. Peptide-enhanced oral delivery of therapeutic peptides and proteins. Journal of Drug Delivery Science and Technology. 2013;23(4):365-373.

Author

Kristensen, Mie ; Foged, Camilla ; Berthelsen, Jens ; Nielsen, Hanne Mørck. / Peptide-enhanced oral delivery of therapeutic peptides and proteins. In: Journal of Drug Delivery Science and Technology. 2013 ; Vol. 23, No. 4. pp. 365-373.

Bibtex

@article{4d115dd81c964ba583a950195dd2ad22,
title = "Peptide-enhanced oral delivery of therapeutic peptides and proteins",
abstract = "Systemic therapy upon oral delivery of biologics, such as peptide and protein drugs is limited due to their large molecular size, their low enzymatic stability and their inability to cross the intestinal epithelium. Ways to overcome the epithelial barrier include the use of peptide-based excipients such as the cell penetrating peptides (CPPs) and the tight junction modulating peptides (TJMPs), which are able to translocate across the cellular membranes in a non-disruptive way or reversibly modulate the integrity of intercellular tight junctions (TJs), respectively. However, because of the harsh environment throughout the gastrointestinal (GI) tract, chemical stability is an inherent challenge when employing amino acid-based excipients for oral delivery, and multiple approaches have been investigated to improve this. The exact mechanisms of transepithelial translocation are discussed, and it is believed that CPP-mediated translocation involves transcytosis and/or direct translocation through the epithelial cells; whereas TJMP-mediated translocation is dependent on interaction with transmembrane or peripheral TJ proteins. This review focuses on the CPPs and the TJMPs currently employed as excipients for oral delivery of peptide and protein drugs highlighting recent studies and the most promising compounds from these classes of peptide excipients.",
author = "Mie Kristensen and Camilla Foged and Jens Berthelsen and Nielsen, {Hanne M{\o}rck}",
year = "2013",
language = "English",
volume = "23",
pages = "365--373",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Peptide-enhanced oral delivery of therapeutic peptides and proteins

AU - Kristensen, Mie

AU - Foged, Camilla

AU - Berthelsen, Jens

AU - Nielsen, Hanne Mørck

PY - 2013

Y1 - 2013

N2 - Systemic therapy upon oral delivery of biologics, such as peptide and protein drugs is limited due to their large molecular size, their low enzymatic stability and their inability to cross the intestinal epithelium. Ways to overcome the epithelial barrier include the use of peptide-based excipients such as the cell penetrating peptides (CPPs) and the tight junction modulating peptides (TJMPs), which are able to translocate across the cellular membranes in a non-disruptive way or reversibly modulate the integrity of intercellular tight junctions (TJs), respectively. However, because of the harsh environment throughout the gastrointestinal (GI) tract, chemical stability is an inherent challenge when employing amino acid-based excipients for oral delivery, and multiple approaches have been investigated to improve this. The exact mechanisms of transepithelial translocation are discussed, and it is believed that CPP-mediated translocation involves transcytosis and/or direct translocation through the epithelial cells; whereas TJMP-mediated translocation is dependent on interaction with transmembrane or peripheral TJ proteins. This review focuses on the CPPs and the TJMPs currently employed as excipients for oral delivery of peptide and protein drugs highlighting recent studies and the most promising compounds from these classes of peptide excipients.

AB - Systemic therapy upon oral delivery of biologics, such as peptide and protein drugs is limited due to their large molecular size, their low enzymatic stability and their inability to cross the intestinal epithelium. Ways to overcome the epithelial barrier include the use of peptide-based excipients such as the cell penetrating peptides (CPPs) and the tight junction modulating peptides (TJMPs), which are able to translocate across the cellular membranes in a non-disruptive way or reversibly modulate the integrity of intercellular tight junctions (TJs), respectively. However, because of the harsh environment throughout the gastrointestinal (GI) tract, chemical stability is an inherent challenge when employing amino acid-based excipients for oral delivery, and multiple approaches have been investigated to improve this. The exact mechanisms of transepithelial translocation are discussed, and it is believed that CPP-mediated translocation involves transcytosis and/or direct translocation through the epithelial cells; whereas TJMP-mediated translocation is dependent on interaction with transmembrane or peripheral TJ proteins. This review focuses on the CPPs and the TJMPs currently employed as excipients for oral delivery of peptide and protein drugs highlighting recent studies and the most promising compounds from these classes of peptide excipients.

M3 - Review

VL - 23

SP - 365

EP - 373

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

IS - 4

ER -

ID: 188882265