PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients
Research output: Contribution to journal › Journal article › Research › peer-review
Recently, an amino acid variant (K121Q) in the glycoprotein PC-1 (Q allele) has been associated with faster progression of diabetic nephropathy, as estimated by calculated creatinine clearance. We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique.
|Journal||Nephrology, Dialysis, Transplantation|
|Number of pages||5|
|Publication status||Published - 2002|
- Adult, Age of Onset, Amino Acid Substitution, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Disease Progression, Female, Follow-Up Studies, Genetic Variation, Genotype, Glomerular Filtration Rate, Heterozygote Detection, Humans, Male, Phosphoric Diester Hydrolases, Pyrophosphatases, Time Factors