PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

Research output: Contribution to journalJournal articleResearchpeer-review

Peter Jacobsen, Niels Grarup, Lise Tarnow, Hans-Henrik Parving, Oluf Pedersen

Recently, an amino acid variant (K121Q) in the glycoprotein PC-1 (Q allele) has been associated with faster progression of diabetic nephropathy, as estimated by calculated creatinine clearance. We tested the impact of the PC-1 (K121Q) variant on loss of glomerular filtration rate (GFR) measured by the [(51)Cr]EDTA plasma clearance technique.
Original languageEnglish
JournalNephrology, Dialysis, Transplantation
Volume17
Issue number8
Pages (from-to)1408-12
Number of pages5
ISSN0931-0509
Publication statusPublished - 2002

    Research areas

  • Adult, Age of Onset, Amino Acid Substitution, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Disease Progression, Female, Follow-Up Studies, Genetic Variation, Genotype, Glomerular Filtration Rate, Heterozygote Detection, Humans, Male, Phosphoric Diester Hydrolases, Pyrophosphatases, Time Factors

ID: 38457959