Oxytocin and vasopressin systems in obesity and metabolic health: Mechanisms and perspectives
Research output: Contribution to journal › Review › Research › peer-review
Cherlyn Ding, Faidon Magkos
Purpose of review: The neurohypophysial endocrine system is identified here as a potential target for therapeutic interventions toward improving obesity-related metabolic dysfunction, given its coinciding pleiotropic effects on psychological, neurological and metabolic systems that are disrupted in obesity.
Recent findings: Copeptin, the C-terminal portion of the precursor of arginine-vasopressin, is positively associated with body mass index and risk of type 2 diabetes. Plasma oxytocin is decreased in obesity and several other conditions of abnormal glucose homeostasis. Recent data also show non-classical tissues, such as myocytes, hepatocytes and β-cells, exhibit responses to oxytocin and vasopressin receptor binding that may contribute to alterations in metabolic function.
Summary: The modulation of anorexigenic and orexigenic pathways appears to be the dominant mechanism underlying the effects of oxytocin and vasopressin on body weight regulation; however, there are apparent limitations associated with their use in direct pharmacological applications. A clearer picture of their wider physiological effects is needed before either system can be considered for therapeutic use.
|Journal||Current Obesity Reports|
|Number of pages||16|
|Publication status||Published - 2019|
- The Faculty of Science - Insulin resistance, Beta-cell function, Energy exoenditure, Neurohypophysis, Substrate metabolism, Vasopressin