Oxyntomodulin: actions and role in diabetes

Research output: Contribution to journalReviewResearchpeer-review

Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
Publication statusPublished - 2018

    Research areas

  • Journal Article, Review, Diabetes, Oxyntomodulin, Proglucagon

ID: 189765037