Oral treatment with improves insulin sensitivity in mice

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Shanthadevi Udayappan, Louise Manneras-Holm, Alice Chaplin-Scott, Clara Belzer, Hilde Herrema, Geesje M Dallinga-Thie, Silvia H Duncan, Erik S G Stroes, Albert K Groen, Harry J Flint, Fredrik Backhed, Willem M de Vos, Max Nieuwdorp

An altered intestinal microbiota composition is associated with insulin resistance and type 2 diabetes mellitus. We previously identified increased intestinal levels of Eubacterium hallii, an anaerobic bacterium belonging to the butyrate-producing Lachnospiraceae family, in metabolic syndrome subjects who received a faecal transplant from a lean donor. To further assess the effects of E. hallii on insulin sensitivity, we orally treated obese and diabetic db/db mice with alive E. hallii and glycerol or heat-inactive E. hallii as control. Insulin tolerance tests and hyperinsulinemic-euglycemic clamp experiments revealed that alive E. hallii treatment improved insulin sensitivity compared control treatment. In addition, E. hallii treatment increased energy expenditure in db/db mice. Active E. hallii treatment was found to increase faecal butyrate concentrations and to modify bile acid metabolism compared with heat-inactivated controls. Our data suggest that E. hallii administration potentially alters the function of the intestinal microbiome and that microbial metabolites may contribute to the improved metabolic phenotype.

Original languageEnglish
Article number16009
JournalNPJ biofilms and microbiomes
Number of pages10
Publication statusPublished - 2016

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ID: 198828726