Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

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Marte W Gustavsen, Marte K Viken, Elisabeth G Celius, Tone Berge, Inger-Lise Mero, Pål Berg-Hansen, Jan H Aarseth, Kjell-Morten Myhr, Helle B Søndergaard, Finn Sellebjerg, Annette B Oturai, Jan Hillert, Lars Alfredsson, Tomas Olsson, Ingrid Kockum, Benedicte A Lie, Hanne F Harbo

Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

Original languageEnglish
JournalJournal of Neuroimmunology
Issue number1-2
Pages (from-to)174-179
Number of pages6
Publication statusPublished - 15 Sep 2014

    Research areas

  • Adult, Female, HLA-DRB1 Chains, Haplotypes, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Killer Cells, Natural, Ligands, Male, Multiple Sclerosis, Relapsing-Remitting, Oligoclonal Bands, Phenotype, Receptors, KIR2DL1, Receptors, KIR2DL2, Receptors, KIR2DL3, Registries

ID: 137965363