Novel Mechanisms in mTORC1-regulated Muscle Plasticity

Research output: Book/ReportPh.D. thesisResearch

Agnete Louise Bjerregaard Madsen

Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.

In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.

In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.

Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.
Original languageEnglish
Place of PublicationCopenhagen
PublisherDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
Number of pages87
ISBN (Print)978-87-7209-211-9
Publication statusPublished - 2018

    Research areas

  • The Faculty of Science - mTORC1, AMPK, ULK1, Autophagy, Skeletal muscle, Muscle plasticity, Molecular mechanisms, Cross-talk between anabolic and catabolic signalling pathways, Physical activity

ID: 209385689