Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes

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Camilla Helene Sandholt, Mette S Mogensen, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Thorkild I A Sørensen, Lars Hansen, Katrine Almind, Torben Jørgensen, Oluf Pedersen, Torben Hansen

The INSIG2 rs7566605 and PFKP rs6602024 polymorphisms have been identified as obesity gene variants in genome-wide association (GWA) studies. However, replication has been contradictory for both variants. The aims of this study were to validate these obesity-associations through case-control studies and analyses of obesity-related quantitative traits. Moreover, since environmental and genetic factors may modulate the impact of a genetic variant, we wanted to perform such interaction analyses. We focused on physical activity as an environmental risk factor, and on the GWA identified obesity variants in FTO (rs9939609) and near MC4R (rs17782313) as genetic risk factors.
Original languageEnglish
JournalPLoS ONE
Issue number8
Pages (from-to)e2872
Number of pages6
Publication statusPublished - 2008

    Research areas

  • Blood Platelets, DNA Replication, Denmark, Exercise, Female, Genetic Variation, Genome, Human, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Male, Membrane Proteins, Motor Activity, Obesity, Overweight, Phosphofructokinases, Polymorphism, Genetic

ID: 10854692