No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

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Jens Drachmann Bukh, Camilla Bock, Maj Vinberg, Thomas Werge, Ulrik Gether, Lars Vedel Kessing, Jens Drachmann Bukh, Camilla Bock, Maj Vinberg, Thomas Werge, Ulrik Gether, Lars Vedel Kessing

Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.
Original languageEnglish
JournalEuropean Neuropsychopharmacology
ISSN0924-977X
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Adult; Alleles; Antidepressive Agents; Depressive Disorder; Female; Genetic Predisposition to Disease; Genotype; Humans; Life Change Events; Male; Middle Aged; Polymorphism, Genetic; Questionnaires; Severity of Illness Index; Stress, Psychological; Treatment Outcome

ID: 21406163