No evidence of transmission of chronic lymphocytic leukemia through blood transfusion

Research output: Contribution to journalLetterResearchpeer-review

Henrik Hjalgrim, Klaus Rostgaard, Senthil K Vasan, Henrik Ullum, Christian Erikstrup, Ole B V Pedersen, Kaspar Rosengreen Nielsen, Kjell-Einar Titlestad, Mads Melbye, Olof Nyrén, Gustaf Edgren

Monoclonal B-cell lymphocytosis (MBL) is a precursor of chronic lymphocytic leukemia (CLL). Observations of MBL in blood donors raise concern that transmitted MBL may cause recipient CLL. Using a database with health information on 1.5 million donors and 2.1 million recipients, we compared CLL occurrence among 7413 recipients of blood from 796 donors diagnosed with CLL after donation cessation, and among 80, 431 recipients of blood from 7477 matched CLL-free donors. During follow-up, 12 and 107 cases of CLL occurred among the exposed and unexposed recipients, respectively, yielding a relative risk of 0.94 (95% confidence interval, 0.52-1.71). Analyses using the entire database showed no evidence of CLL clustering among recipients of blood from individual donors. In conclusion, when donor MBL was approximated by subsequent donor CLL diagnosis, data from 2 countries' entire computerized transfusion experience over more than 30 years indicate that MBL/CLL transmission does not contribute importantly to recipient CLL risk.

Original languageEnglish
JournalBlood
Volume126
Issue number17
Pages (from-to)2059-61
Number of pages3
ISSN0006-4971
DOIs
Publication statusPublished - 22 Oct 2015

    Research areas

  • B-Lymphocytes, Blood Donors, Blood Transfusion, Follow-Up Studies, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Count, Lymphocytosis, Prognosis, Scandinavian and Nordic Countries, Journal Article, Research Support, Non-U.S. Gov't

ID: 180570200