Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

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David E. Gloriam, Helgi B Schiöth, Robert Fredriksson

We report nine new members of the Rhodopsin family of human G protein-coupled receptors (GPCRs) found by searches in the genome databases. BLAST searches and phylogenetic analyses showed that only four of the receptors are closely related to previously characterised GPCRs, GPR150 and GPR154 to oxytocin/vasopressin receptors, GPR152 to CRTH2/FPRs and GPR165 to GPR72/NPYR. Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives. We have identified in total 37 orthologues for the new receptors, primarily from rat, mouse, chicken, fugu and zebrafish. GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly. Analyses using expressed sequence tags (ESTs) indicate that all the new receptors except GPR153 have the CNS as a major site of expression.
Original languageEnglish
JournalBBA General Subjects
Volume1722
Issue number3
Pages (from-to)235-46
Number of pages12
ISSN0304-4165
DOIs
Publication statusPublished - 15 Apr 2005
Externally publishedYes

    Research areas

  • Expressed Sequence Tags, Humans, Phylogeny, Receptors, G-Protein-Coupled, Rhodopsin

ID: 45811696