Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA

Research output: PatentResearch

Camilla Foged (Inventor), Henrik Franzyk (Inventor), Xianghui Zeng (Inventor), Hanne Mørck Nielsen (Inventor), Kaushik Thanki (Inventor)

The present invention relates to a nanoparticle compn. comprising PLGA derivs. and a lipid. The compn. is suitable for medical use. Particularly, the present invention relates to a delivery system for delivery of drugs, in particular nucleic acids, with enhanced efficacy and reduced adverse effects, such as reduced toxicity and immunogenicity, on healthy tissue. More precisely, the present invention relates to a delivery system comprising hybrid nanoparticles comprising PLGA and lipidoids for the delivery of siRNA.
Original languageEnglish
IPCA61K31/713,A61K47/18,A61K47/34,A61K9/51,A61P25/00,A61P29/00,A61P35/00
Patent numberWO2017158093-A1
Filing date16/03/2017
CountryDenmark
Priority date17/03/2016
Priority numberEP 2016-160931
Publication statusPublished - 21 Sep 2017

ID: 199168708