Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography

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Standard

Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure : a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography. / Byrne, Christina; Hasbak, Philip; Kjær, Andreas; Thune, Jens Jakob; Køber, Lars.

In: European Heart Journal Cardiovascular Imaging, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Byrne, C, Hasbak, P, Kjær, A, Thune, JJ & Køber, L 2019, 'Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography', European Heart Journal Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jey089

APA

Byrne, C., Hasbak, P., Kjær, A., Thune, J. J., & Køber, L. (2019). Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography. European Heart Journal Cardiovascular Imaging, [jey089]. https://doi.org/10.1093/ehjci/jey089

Vancouver

Byrne C, Hasbak P, Kjær A, Thune JJ, Køber L. Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography. European Heart Journal Cardiovascular Imaging. 2019. jey089. https://doi.org/10.1093/ehjci/jey089

Author

Byrne, Christina ; Hasbak, Philip ; Kjær, Andreas ; Thune, Jens Jakob ; Køber, Lars. / Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure : a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography. In: European Heart Journal Cardiovascular Imaging. 2019.

Bibtex

@article{0829048dcb1d4437b4a287c05f5a24bb,
title = "Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure: a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography",
abstract = "Aims: Patients with non-ischaemic systolic heart failure often have reduced myocardial blood flow without significant coronary atherosclerosis. Likewise, patients with atrial fibrillation (AF) have reduced myocardial perfusion during AF compared with sinus rhythm. The aim of this study was to explore whether there is an additive negative effect of AF during scan on the myocardial perfusion in patients with non-ischaemic systolic heart failure.Methods and results: We included 27 young healthy controls and 114 patients with non-ischaemic systolic heart failure to a Rubidium-82 positron emission tomography/computed tomography perfusion scan (23 with AF during scan). To obtain the myocardial flow reserve (MFR = stress flow/rest flow), patients were scanned at rest and during adenosine-induced stress. Among patients, those with AF were older [years: 73; interquartile range (IQR) 65-78 vs. 67; IQR 60-74; P = 0.03] and more were men (87{\%} vs. 62{\%}; P = 0.02). Distribution of sex in controls did not differ from either patient group. Patients with AF had significantly lower MFR than patients without [MFR: 1.87; 95{\%} confidence interval (CI) 1.58-2.22 vs. 2.50; 95{\%} CI 2.06-2.86; percent difference: -21.5{\%}; P = 0.01]. MFR remained significantly lower in the group with AF (estimate -24.2{\%}; 95{\%} CI -39.6{\%} to -4.8{\%}; P = 0.02) in an adjusted multivariable regression analysis. Further, patients had lower MFR compared with controls: 3.46; 95{\%} CI 3.03-3.94; P < 0.0001. Additionally, coronary vascular resistance was highest in patients with AF and lowest in controls.Conclusion: Patients with systolic heart failure had lower flow reserve than healthy controls and even lower MFR if they had AF during scan.",
author = "Christina Byrne and Philip Hasbak and Andreas Kj{\ae}r and Thune, {Jens Jakob} and Lars K{\o}ber",
year = "2019",
doi = "10.1093/ehjci/jey089",
language = "English",
journal = "European Heart Journal Cardiovascular Imaging",
issn = "1525-2167",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Myocardial perfusion during atrial fibrillation in patients with non-ischaemic systolic heart failure

T2 - a cross-sectional study using Rubidium-82 positron emission tomography/computed tomography

AU - Byrne, Christina

AU - Hasbak, Philip

AU - Kjær, Andreas

AU - Thune, Jens Jakob

AU - Køber, Lars

PY - 2019

Y1 - 2019

N2 - Aims: Patients with non-ischaemic systolic heart failure often have reduced myocardial blood flow without significant coronary atherosclerosis. Likewise, patients with atrial fibrillation (AF) have reduced myocardial perfusion during AF compared with sinus rhythm. The aim of this study was to explore whether there is an additive negative effect of AF during scan on the myocardial perfusion in patients with non-ischaemic systolic heart failure.Methods and results: We included 27 young healthy controls and 114 patients with non-ischaemic systolic heart failure to a Rubidium-82 positron emission tomography/computed tomography perfusion scan (23 with AF during scan). To obtain the myocardial flow reserve (MFR = stress flow/rest flow), patients were scanned at rest and during adenosine-induced stress. Among patients, those with AF were older [years: 73; interquartile range (IQR) 65-78 vs. 67; IQR 60-74; P = 0.03] and more were men (87% vs. 62%; P = 0.02). Distribution of sex in controls did not differ from either patient group. Patients with AF had significantly lower MFR than patients without [MFR: 1.87; 95% confidence interval (CI) 1.58-2.22 vs. 2.50; 95% CI 2.06-2.86; percent difference: -21.5%; P = 0.01]. MFR remained significantly lower in the group with AF (estimate -24.2%; 95% CI -39.6% to -4.8%; P = 0.02) in an adjusted multivariable regression analysis. Further, patients had lower MFR compared with controls: 3.46; 95% CI 3.03-3.94; P < 0.0001. Additionally, coronary vascular resistance was highest in patients with AF and lowest in controls.Conclusion: Patients with systolic heart failure had lower flow reserve than healthy controls and even lower MFR if they had AF during scan.

AB - Aims: Patients with non-ischaemic systolic heart failure often have reduced myocardial blood flow without significant coronary atherosclerosis. Likewise, patients with atrial fibrillation (AF) have reduced myocardial perfusion during AF compared with sinus rhythm. The aim of this study was to explore whether there is an additive negative effect of AF during scan on the myocardial perfusion in patients with non-ischaemic systolic heart failure.Methods and results: We included 27 young healthy controls and 114 patients with non-ischaemic systolic heart failure to a Rubidium-82 positron emission tomography/computed tomography perfusion scan (23 with AF during scan). To obtain the myocardial flow reserve (MFR = stress flow/rest flow), patients were scanned at rest and during adenosine-induced stress. Among patients, those with AF were older [years: 73; interquartile range (IQR) 65-78 vs. 67; IQR 60-74; P = 0.03] and more were men (87% vs. 62%; P = 0.02). Distribution of sex in controls did not differ from either patient group. Patients with AF had significantly lower MFR than patients without [MFR: 1.87; 95% confidence interval (CI) 1.58-2.22 vs. 2.50; 95% CI 2.06-2.86; percent difference: -21.5%; P = 0.01]. MFR remained significantly lower in the group with AF (estimate -24.2%; 95% CI -39.6% to -4.8%; P = 0.02) in an adjusted multivariable regression analysis. Further, patients had lower MFR compared with controls: 3.46; 95% CI 3.03-3.94; P < 0.0001. Additionally, coronary vascular resistance was highest in patients with AF and lowest in controls.Conclusion: Patients with systolic heart failure had lower flow reserve than healthy controls and even lower MFR if they had AF during scan.

U2 - 10.1093/ehjci/jey089

DO - 10.1093/ehjci/jey089

M3 - Journal article

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

SN - 1525-2167

M1 - jey089

ER -

ID: 202033329