Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Research output: Contribution to journalJournal articleResearchpeer-review

Alon Barsheshet, Ilan Goldenberg, Jin O-Uchi, Arthur J Moss, Christian Jons, Wataru Shimizu, Arthur A Wilde, Scott McNitt, Derick R Peterson, Wojciech Zareba, Jennifer L Robinson, Michael J Ackerman, Michael Cypress, Daniel A Gray, Nynke Hofman, Jørgen K. Kanters, Elizabeth S Kaufman, Pyotr G Platonov, Ming Qi, Jeffrey A Towbin & 2 others G Michael Vincent, Coeli M Lopes

β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location.
Original languageEnglish
JournalCirculation
Volume125
Issue number16
Pages (from-to)1988-96
Number of pages9
ISSN0009-7322
DOIs
Publication statusPublished - 24 Apr 2012

    Research areas

  • Adolescent, Adrenergic beta-Antagonists, Adult, Child, Female, Genetic Predisposition to Disease, Heart Arrest, Humans, KCNQ1 Potassium Channel, Male, Mutation, Risk, Romano-Ward Syndrome, Treatment Outcome, Young Adult

ID: 48052006