Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells

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Camilla Kappe, Cesare Patrone, Jens Juul Holst, Qimin Zhang, Ake Sjöholm

Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
Original languageEnglish
JournalJournal of Gastroenterology
Volume48
Issue number3
Pages (from-to)322-32
Number of pages11
ISSN0944-1174
DOIs
Publication statusPublished - Mar 2013

ID: 45840439