Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
Research output: Contribution to journal › Journal article › Research › peer-review
Camilla Kappe, Cesare Patrone, Jens Juul Holst, Qimin Zhang, Ake Sjöholm
Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin therapy have elevated levels of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and metformin has been shown to regulate the expression of the GLP-1R in the pancreas.
|Journal||Journal of Gastroenterology|
|Number of pages||11|
|Publication status||Published - Mar 2013|