Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women : A Pooled Analysis Including 15 Study Populations. / Beenakker, Karel G M; Westendorp, Rudi G J; de Craen, Anton J M; Chen, Sijia; Raz, Yotam; Ballieux, Bart E P B; Nelissen, Rob G H H; Later, Alexander F L; Huizinga, Tom W; Slagboom, Pieternella E; Boomsma, Dorret I; Maier, Andrea B.

In: Journal of Innate Immunity, 21.06.2019, p. 1-12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Beenakker, KGM, Westendorp, RGJ, de Craen, AJM, Chen, S, Raz, Y, Ballieux, BEPB, Nelissen, RGHH, Later, AFL, Huizinga, TW, Slagboom, PE, Boomsma, DI & Maier, AB 2019, 'Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations', Journal of Innate Immunity, pp. 1-12. https://doi.org/10.1159/000499840

APA

Beenakker, K. G. M., Westendorp, R. G. J., de Craen, A. J. M., Chen, S., Raz, Y., Ballieux, B. E. P. B., ... Maier, A. B. (2019). Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. Journal of Innate Immunity, 1-12. https://doi.org/10.1159/000499840

Vancouver

Beenakker KGM, Westendorp RGJ, de Craen AJM, Chen S, Raz Y, Ballieux BEPB et al. Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations. Journal of Innate Immunity. 2019 Jun 21;1-12. https://doi.org/10.1159/000499840

Author

Beenakker, Karel G M ; Westendorp, Rudi G J ; de Craen, Anton J M ; Chen, Sijia ; Raz, Yotam ; Ballieux, Bart E P B ; Nelissen, Rob G H H ; Later, Alexander F L ; Huizinga, Tom W ; Slagboom, Pieternella E ; Boomsma, Dorret I ; Maier, Andrea B. / Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women : A Pooled Analysis Including 15 Study Populations. In: Journal of Innate Immunity. 2019 ; pp. 1-12.

Bibtex

@article{59b007755a11453ca4b868663aed02e3,
title = "Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations",
abstract = "The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine data from 15 study populations. Individual data on ex vivo cytokine production response upon stimulation with LPS in whole blood were available for 4,020 subjects originating from these 15 study populations, either from the general population or from patient populations with specific diseases. Men had a stronger cytokine production response than women to LPS for tumour necrosis factor-α, interleukin (IL)-6, IL-12, IL-1β, IL-1RA, and IL-10, but not for interferon-γ. The granulocyte-macrophage colony-stimulating factor production response was lower in men than in women. These sex differences were independent of chronological age. As men had higher monocyte concentrations, we normalized the cytokine production responses for monocyte concentration. After normalization, the sex differences in cytokine production response to LPS disappeared, except for IL-10, for which the production response was lower in men than in women. A sex-based approach to interpreting immune responsiveness is crucial.",
author = "Beenakker, {Karel G M} and Westendorp, {Rudi G J} and {de Craen}, {Anton J M} and Sijia Chen and Yotam Raz and Ballieux, {Bart E P B} and Nelissen, {Rob G H H} and Later, {Alexander F L} and Huizinga, {Tom W} and Slagboom, {Pieternella E} and Boomsma, {Dorret I} and Maier, {Andrea B}",
note = "{\circledC} 2019 The Author(s) Published by S. Karger AG, Basel.",
year = "2019",
month = "6",
day = "21",
doi = "10.1159/000499840",
language = "English",
pages = "1--12",
journal = "Journal of Innate Immunity",
issn = "1662-811X",
publisher = "S Karger AG",

}

RIS

TY - JOUR

T1 - Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women

T2 - A Pooled Analysis Including 15 Study Populations

AU - Beenakker, Karel G M

AU - Westendorp, Rudi G J

AU - de Craen, Anton J M

AU - Chen, Sijia

AU - Raz, Yotam

AU - Ballieux, Bart E P B

AU - Nelissen, Rob G H H

AU - Later, Alexander F L

AU - Huizinga, Tom W

AU - Slagboom, Pieternella E

AU - Boomsma, Dorret I

AU - Maier, Andrea B

N1 - © 2019 The Author(s) Published by S. Karger AG, Basel.

PY - 2019/6/21

Y1 - 2019/6/21

N2 - The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine data from 15 study populations. Individual data on ex vivo cytokine production response upon stimulation with LPS in whole blood were available for 4,020 subjects originating from these 15 study populations, either from the general population or from patient populations with specific diseases. Men had a stronger cytokine production response than women to LPS for tumour necrosis factor-α, interleukin (IL)-6, IL-12, IL-1β, IL-1RA, and IL-10, but not for interferon-γ. The granulocyte-macrophage colony-stimulating factor production response was lower in men than in women. These sex differences were independent of chronological age. As men had higher monocyte concentrations, we normalized the cytokine production responses for monocyte concentration. After normalization, the sex differences in cytokine production response to LPS disappeared, except for IL-10, for which the production response was lower in men than in women. A sex-based approach to interpreting immune responsiveness is crucial.

AB - The incidence of bacterial infections and sepsis, as well as the mortality risk from sepsis, is sex specific. These clinical findings have been attributed to sex differences in immune responsiveness. The aim of the present study was to investigate sex differences in monocyte-derived cytokine production response upon stimulation with the gram-negative stimulus lipopolysaccharide (LPS) using cytokine data from 15 study populations. Individual data on ex vivo cytokine production response upon stimulation with LPS in whole blood were available for 4,020 subjects originating from these 15 study populations, either from the general population or from patient populations with specific diseases. Men had a stronger cytokine production response than women to LPS for tumour necrosis factor-α, interleukin (IL)-6, IL-12, IL-1β, IL-1RA, and IL-10, but not for interferon-γ. The granulocyte-macrophage colony-stimulating factor production response was lower in men than in women. These sex differences were independent of chronological age. As men had higher monocyte concentrations, we normalized the cytokine production responses for monocyte concentration. After normalization, the sex differences in cytokine production response to LPS disappeared, except for IL-10, for which the production response was lower in men than in women. A sex-based approach to interpreting immune responsiveness is crucial.

U2 - 10.1159/000499840

DO - 10.1159/000499840

M3 - Journal article

SP - 1

EP - 12

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

SN - 1662-811X

ER -

ID: 224090237