Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
Niels Grarup, Ida Moltke, Mette Korre Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Sebastian Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina Viskum Lytken Larsen, Inger Katrine Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Borbye Pedersen, Robin Andersson, Peter Bjerregaard, Marit Eika Jørgensen, Anders Albrechtsen, Torben Hansen
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
|Number of pages||3|
|Publication status||Published - 2018|