Linking Microbiota to Human Diseases: A Systems Biology Perspective

Research output: Contribution to journalReviewResearchpeer-review

Hao Wu, Valentina Tremaroli, F Bäckhed

The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.

Original languageEnglish
JournalTrends in Endocrinology and Metabolism
Issue number12
Pages (from-to)758-70
Number of pages13
Publication statusPublished - 6 Nov 2015

ID: 150712119