Light sensitive chloramphenicol analogues

Research output: Contribution to journalJournal articleResearchpeer-review

V Leick, O Buchardt, Peter E. Nielsen

Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the "fragment reaction" assay, and for their ability to generate very reactive species upon irradiation.

Original languageEnglish
JournalDalton Transactions (Print Edition)
Volume29
Issue number6
Pages (from-to)662-6
Number of pages5
ISSN0302-4369
Publication statusPublished - 1975

    Research areas

  • Chloramphenicol/analogs & derivatives, Depression, Chemical, Escherichia coli/enzymology, Light, Peptidyl Transferases/metabolism, Photochemistry, Radiation Effects, Ribosomes/enzymology, Ultraviolet Rays

ID: 203632082