Lifelong football training: Effects on autophagy and healthy longevity promotion

Research output: Contribution to journalJournal articleResearchpeer-review

Documents

Annamaria Mancini, Daniela Vitucci, Morten Bredsgaard Randers, Jakob Friis Schmidt, Marie Hagman, Thomas Rostgaard Andersen, Esther Imperlini, Annalisa Mandola, Stefania Orrù, Peter Krustrup, Pasqualina Buono

Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.

Original languageEnglish
Article number132
JournalFrontiers in Physiology
Volume10
Number of pages12
ISSN1664-042X
DOIs
Publication statusPublished - 2019

    Research areas

  • The Faculty of Science - Football, Lifelong training, Longevity, Cardiovascular capacity, Autophagy

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 214683553