Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?

Research output: Contribution to journalJournal articleResearchpeer-review

Daniël H van Raalte, Kelly A A Kwa, Renate E van Genugten, Maarten E Tushuizen, Jens Juul Holst, Carolyn F Deacon, John M Karemaker, Robert J Heine, Andrea Mari, Michaela Diamant

Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system.
Original languageEnglish
JournalMetabolism
Volume62
Issue number4
Pages (from-to)568-577
Number of pages10
ISSN0026-0495
DOIs
Publication statusPublished - 2013

    Research areas

  • Adolescent, Adult, Anthropometry, Arginine, Blood Glucose, Dose-Response Relationship, Drug, Double-Blind Method, Glucagon, Glucocorticoids, Glucose Clamp Technique, Heart Rate, Humans, Hyperglycemia, Incretins, Islets of Langerhans, Male, Pancreatic Diseases, Pancreatic Function Tests, Prednisolone, Stimulation, Chemical, Sympathetic Nervous System, Vagus Nerve, Young Adult

ID: 45682263