Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

Research output: Contribution to journalJournal articleResearchpeer-review

Marli A Robertson, David L Sigalet, Jens Juul Holst, Jon B Meddings, Julie Wood, Keith A Sharkey

We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.

Original languageEnglish
JournalJournal of Autism and Developmental Disorders
Volume38
Issue number6
Pages (from-to)1066-71
Number of pages6
ISSN0162-3257
DOIs
Publication statusPublished - Jul 2008

    Research areas

  • Autistic Disorder, Child, Child, Preschool, Female, Glucagon-Like Peptide 2, Humans, Intestinal Absorption, Intestine, Small, Lactulose, Male, Mannitol, Pilot Projects, Reference Values, Satiety Response

ID: 132049280