Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Research output: Contribution to journalReviewResearchpeer-review

Annika Wahlström, Sama I Sayin, Hanns-Ulrich Marschall, Gert Fredrik Bäckhed

The gut microbiota is considered a metabolic "organ" that not only facilitates harvesting of nutrients and energy from the ingested food but also produces numerous metabolites that signal through their cognate receptors to regulate host metabolism. One such class of metabolites, bile acids, is produced in the liver from cholesterol and metabolized in the intestine by the gut microbiota. These bioconversions modulate the signaling properties of bile acids via the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate numerous metabolic pathways in the host. Conversely, bile acids can modulate gut microbial composition both directly and indirectly through activation of innate immune genes in the small intestine. Thus, host metabolism can be affected through microbial modifications of bile acids, which lead to altered signaling via bile acid receptors, but also by altered microbiota composition.

Original languageEnglish
JournalCell Metabolism
Volume24
Issue number1
Pages (from-to)41-50
Number of pages10
ISSN1550-4131
DOIs
Publication statusPublished - 12 Jul 2016

    Research areas

  • Journal Article, Review

ID: 166691056