Interaktion mellem warfarin og oral miconazol-gel

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We report a case of a 76 year-old woman who had been taking warfarin for seven years because of relapsing deep venous thrombosis. Her daily maintenance dose was 5 mg. Monthly measurements of international normalised ratio (INR) were stable between 2-3. She developed oral candidiasis and miconazole gel was prescribed. One week later she developed bleeding gums. Eight days later she was admitted to the hospital with haematuria. INR was > 10. Warfarin and the miconazole gel were withdrawn. She was treated with phytonadione. INR normalised after four days and she continued warfarin treatment. Caution should be exercised whenever the combination of warfarin and miconazole gel are prescribed.
Original languageDanish
JournalUgeskrift for Laeger
Volume162
Issue number41
Pages (from-to)5511
ISSN0041-5782
Publication statusPublished - 9 Oct 2000

ID: 92191904