Inhibition of glucagon secretion by GLP-1 agonists and DPP4 inhibitors

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Morten Hansen, Kristine Juul Hare, Jens Juul Holst, Filip Krag Knop

Incretin-based treatments have emerged as new modalities for the treatment of type 2 diabetes mellitus (T2DM). In contrast to current
antidiabetic treatments, these agents target both insulin insufficiency and inappropriate hyperglucagonemia*two major components of type
2 diabetic pathophysiology*both known to contribute significantly to the hyperglycemic state of patients with T2DM. This article outlines the
role of hyperglucagonemia in type 2 diabetic pathophysiology, summarizes the physiologic effects of glucagon-like peptide-1 (GLP-1), and
gives an introduction to incretin-based treatments with emphasis on their glucagon-lowering effects. Finally, we review available glucagon
data from current clinical studies on incretin-based treatment modalities (dipeptidyl peptidase 4 [DPP4] inhibitors and GLP-1 receptor
agonists). Most of these studies suggest that both DPP4 inhibitors and GLP-1 receptor agonists lower fasting and postprandial plasma
glucagon, and recent data suggest that these effects contribute importantly to the glucose-lowering effect of these treatments.
Original languageEnglish
JournalJournal of Clinical Metabolism & Diabetes
Volume2
Issue number2
Pages (from-to)7-13
Number of pages7
ISSN2041-8019
Publication statusPublished - Jun 2011

ID: 38433556