Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Research output: Contribution to journalJournal articleResearchpeer-review

Peter Roos, Marina Rode von Essen, Troels Tolstrup Nielsen, Peter Johannsen, Jette Stokholm, Anne Sigaard Bie, Gunhild Waldemar, Anja Hviid Simonsen, Amanda Heslegrave, Henrik Zetterberg, FReJA Consortium, Finn Sellebjerg, Jørgen Erik Nielsen

Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume324
Pages (from-to)136-142
Number of pages7
ISSN0165-5728
DOIs
Publication statusPublished - 2018

ID: 216975339