Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Research output: Contribution to journalJournal articleResearchpeer-review

Natakarn Nimsanor, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A Mau-Holzmann, Narisorn Kitiyanant, Jørgen E Nielsen, Troels T Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmid

Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene.

Original languageEnglish
JournalStem Cell Research
Issue number3
Pages (from-to)564-567
Number of pages4
Publication statusPublished - Nov 2016

ID: 172816652