Increased blood BDNF in healthy individuals with a family history of depression

Research output: Contribution to journalJournal articleResearchpeer-review

Ulla Knorr, Mia H Greisen Søndergaard, Pernille Koefoed, Anders Jørgensen, Maria Faurholt-Jepsen, Maj Vinberg, Lars Vedel Kessing

The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with (n = 76), compared with healthy individuals without (n = 39) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals.

Original languageEnglish
JournalPsychiatry Research
Volume256
Pages (from-to)176-179
ISSN0165-1781
DOIs
Publication statusPublished - 2017

ID: 194804191