In situ quantification of local O 2 concentration in 3D bioprinted constructs using luminescent nanoparticles

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

A. R. Akkineni, E. Trampe, K. Koren, A. Lode, F. Krujatz, M. Kühl, Michael Gelinsky

One major limitation of tissue engineering approaches is the insufficient supply of the cells with oxygen due to a lack of a functional vascular system ex vivo. In complex 3D culture systems, such as bioprinted constructs with clinically relevant dimensions (Kilian D. MRS Bull. 2017; 42: 582-592), the local O 2 concentration depends on the macroporosity of the hydrogel scaffold as well as on the permeability of the hydrogel material (bioink) which oxygen has to pass through via diffusion. For better understanding new tools are needed to monitor in real time oxygen distribution dynamics within bioprinted constructs. We propose utilisation of cytocompatible O 2 sensitive luminescent nanoparticles (NP) for this purpose.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019 : The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Number of pages1
PublisherWiley, Periodics, Society for Biomaterials
Publication date1 Jan 2019
ISBN (Electronic)9781510883901
Publication statusPublished - 1 Jan 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 3 Apr 20196 Apr 2019

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
LandUnited States
BySeattle
Periode03/04/201906/04/2019
SeriesTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN1526-7547

ID: 225759753