Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects
Research output: Contribution to journal › Journal article › Research › peer-review
The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
|Journal||Journal of Clinical Endocrinology and Metabolism|
|Number of pages||8|
|Publication status||Published - 2012|
- Adult, Blood Glucose, C-Peptide, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Glucose Clamp Technique, Glucose Intolerance, Glucose Tolerance Test, Humans, Incretins, Infusions, Intravenous, Insulin, Insulin Resistance, Insulin-Secreting Cells, Kinetics, Male, Severity of Illness Index, Young Adult