Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

Research output: Contribution to journalJournal articleResearchpeer-review

Katrine B Hansen, Tina Vilsbøll, Jonatan I Bagger, Jens Juul Holst, Filip K Knop

The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number4
Pages (from-to)1363-70
Number of pages8
ISSN0021-972X
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Blood Glucose, C-Peptide, Gastric Inhibitory Polypeptide, Glucagon, Glucagon-Like Peptide 1, Glucose Clamp Technique, Glucose Intolerance, Glucose Tolerance Test, Humans, Incretins, Infusions, Intravenous, Insulin, Insulin Resistance, Insulin-Secreting Cells, Kinetics, Male, Severity of Illness Index, Young Adult

ID: 40379513