Impact of a multifactorial treatment programme on clinical outcomes and cardiovascular risk estimates: a retrospective cohort study from a specialised diabetes centre in Denmark

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Narges Safai, Bendix Carstensen, Henrik Vestergaard, Martin Ridderstråle

OBJECTIVES: To investigate the impact of a multifactorial treatment programme in a real-life setting on clinical outcomes and estimated cardiovascular disease (CVD) risk.

DESIGN: A retrospective observational cohort study, using data from the electronic medical records and national registers.

SETTING: Tertiary diabetes centre in Denmark.

PARTICIPANTS: Patients with type 2 diabetes (n=4299) referred to a programme with focus on treatment of hyperglycaemia, hypertension and dyslipidaemia between 1 January 2001 and 1 April 2016.

OUTCOMES: Primary outcomes were changes in haemoglobin A1c (HbA1c), blood pressure (BP) and low-density lipoprotein (LDL) cholesterol as well as proportion reaching treatment targets. Our secondary outcome was to investigate changes in antidiabetic, antihypertensive and lipid-lowering treatment, together with the impact on estimated CVD risk. Linear mixed model for repeated measurements were used for continuous variables and logistic regression for dichotomous variables.

RESULTS: The patients achieved a mean±SD decrease in HbA1c, systolic and diastolic BP and LDL cholesterol of 1.0%±0.04% (10.6±0.4 mmol/mol), 6.3±0.4 mm Hg, 2.7±0.2 mm Hg and 0.32±0.02 mmol/L, respectively (p<0.0001). The proportion of patients who met the treatment goal for HbA1c (<7% (<53 mmol/mol)) increased from 31% to 58% (p<0.0001); for BP (<130/80 mm Hg) from 24% to 34% (p<0.0001), and for LDL cholesterol (<2.5 mmol/L (patients without previous CVD) or <1.8 mmol/L (patients with previous CVD)) from 52% to 65%. Those reaching all three guideline treatment targets increased from 4% to 15% (p<0.0001), and when relaxing the BP target to <140/85 from 8% to 24%. The estimated CVD risk was relatively reduced by 15.2% using the Swedish National Diabetes Register risk engine and 30.9% using the UK Prospective Diabetes Study risk engine.

CONCLUSIONS: Our data support that short-term multifactorial treatment of patients with glycaemic dysregulation in a specialist outpatient setting is both achievable and effective, and associated with a clinically meaningful improvement in CVD risk.

Original languageEnglish
Article numbere019214
JournalBMJ Open
Issue number3
Publication statusPublished - 2018

    Research areas

  • Adult, Aged, Antihypertensive Agents/therapeutic use, Blood Glucose/analysis, Blood Pressure/physiology, Cardiovascular Diseases/blood, Cholesterol/blood, Denmark, Diabetes Mellitus, Type 2/complications, Dyslipidemias/drug therapy, Female, Glycated Hemoglobin A/analysis, Humans, Hypertension/drug therapy, Hypoglycemic Agents/therapeutic use, Logistic Models, Male, Middle Aged, Prospective Studies, Retrospective Studies, Risk Factors

ID: 209357873