Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model

Research output: Contribution to journalJournal articleResearchpeer-review

A H Chakera, B S Nielsen, J Madsen, J Romer, P E G Kristjansen, I Buch, Tina Binderup, C Ingvar, A Nalla, A Kjaer, B Hesse, A H Chakera, Boye S. Nielsen, J Madsen, John Rømer, Paul Ejnar Gremaud Kristjansen, I Buch, T Binderup, C Ingvar, Amarnadh Nalla & 2 others Andreas Kjær, B Hesse

Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.
Original languageEnglish
JournalInternational Journal of Molecular Imaging
Volume2011
Pages (from-to)828151
Number of pages7
ISSN2090-1712
DOIs
Publication statusPublished - 2011

ID: 33790867