IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats

Research output: Contribution to journalJournal articleResearchpeer-review

Karen Thomsen, Niels Kristian Aagaard, Henning Grønbæk, Jens Juul Holst, Niels Jessen, Jan Frystyk, Hendrik Vilstrup

Clinical or experimentally induced, active inflammation up-regulates the in vivo capacity of urea synthesis (CUNS), which promotes nitrogen removal from the body and metabolic catabolism. We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration. The described effect of TNF-a on nitrogen homeostasis may, therefore, depend on IL-6.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Issue number2
Pages (from-to)150-156
Number of pages7
Publication statusPublished - Apr 2011

    Research areas

  • Acute-Phase Proteins, Animals, Blood Glucose, Corticosterone, Female, Gene Expression Regulation, Glucagon, Humans, Insulin, Interleukin-6, Liver, RNA, Messenger, Rats, Rats, Wistar, Somatomedins, Urea

ID: 38531833