IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

IL6 gene promoter polymorphisms and type 2 diabetes : joint analysis of individual participants' data from 21 studies. / Huth, Cornelia; Heid, Iris M; Vollmert, Caren; Gieger, Christian; Grallert, Harald; Wolford, Johanna K; Langer, Birgit; Thorand, Barbara; Klopp, Norman; Hamid, Yasmin H; Pedersen, Oluf; Hansen, Torben; Lyssenko, Valeriya; Groop, Leif; Meisinger, Christa; Döring, Angela; Löwel, Hannelore; Lieb, Wolfgang; Hengstenberg, Christian; Rathmann, Wolfgang; Martin, Stephan; Stephens, Jeffrey W; Ireland, Helen; Mather, Hugh; Miller, George J; Stringham, Heather M; Boehnke, Michael; Tuomilehto, Jaakko; Boeing, Heiner; Möhlig, Matthias; Spranger, Joachim; Pfeiffer, Andreas; Wernstedt, Ingrid; Niklason, Anders; López-Bermejo, Abel; Fernández-Real, José-Manuel; Hanson, Robert L; Gallart, Luis; Vendrell, Joan; Tsiavou, Anastasia; Hatziagelaki, Erifili; Humphries, Steve E; Wichmann, H-Erich; Herder, Christian; Illig, Thomas.

In: Diabetes, Vol. 55, No. 10, 2006, p. 2915-21.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Huth, C, Heid, IM, Vollmert, C, Gieger, C, Grallert, H, Wolford, JK, Langer, B, Thorand, B, Klopp, N, Hamid, YH, Pedersen, O, Hansen, T, Lyssenko, V, Groop, L, Meisinger, C, Döring, A, Löwel, H, Lieb, W, Hengstenberg, C, Rathmann, W, Martin, S, Stephens, JW, Ireland, H, Mather, H, Miller, GJ, Stringham, HM, Boehnke, M, Tuomilehto, J, Boeing, H, Möhlig, M, Spranger, J, Pfeiffer, A, Wernstedt, I, Niklason, A, López-Bermejo, A, Fernández-Real, J-M, Hanson, RL, Gallart, L, Vendrell, J, Tsiavou, A, Hatziagelaki, E, Humphries, SE, Wichmann, H-E, Herder, C & Illig, T 2006, 'IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies', Diabetes, vol. 55, no. 10, pp. 2915-21. https://doi.org/10.2337/db06-0600

APA

Huth, C., Heid, I. M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J. K., ... Illig, T. (2006). IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes, 55(10), 2915-21. https://doi.org/10.2337/db06-0600

Vancouver

Huth C, Heid IM, Vollmert C, Gieger C, Grallert H, Wolford JK et al. IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies. Diabetes. 2006;55(10):2915-21. https://doi.org/10.2337/db06-0600

Author

Huth, Cornelia ; Heid, Iris M ; Vollmert, Caren ; Gieger, Christian ; Grallert, Harald ; Wolford, Johanna K ; Langer, Birgit ; Thorand, Barbara ; Klopp, Norman ; Hamid, Yasmin H ; Pedersen, Oluf ; Hansen, Torben ; Lyssenko, Valeriya ; Groop, Leif ; Meisinger, Christa ; Döring, Angela ; Löwel, Hannelore ; Lieb, Wolfgang ; Hengstenberg, Christian ; Rathmann, Wolfgang ; Martin, Stephan ; Stephens, Jeffrey W ; Ireland, Helen ; Mather, Hugh ; Miller, George J ; Stringham, Heather M ; Boehnke, Michael ; Tuomilehto, Jaakko ; Boeing, Heiner ; Möhlig, Matthias ; Spranger, Joachim ; Pfeiffer, Andreas ; Wernstedt, Ingrid ; Niklason, Anders ; López-Bermejo, Abel ; Fernández-Real, José-Manuel ; Hanson, Robert L ; Gallart, Luis ; Vendrell, Joan ; Tsiavou, Anastasia ; Hatziagelaki, Erifili ; Humphries, Steve E ; Wichmann, H-Erich ; Herder, Christian ; Illig, Thomas. / IL6 gene promoter polymorphisms and type 2 diabetes : joint analysis of individual participants' data from 21 studies. In: Diabetes. 2006 ; Vol. 55, No. 10. pp. 2915-21.

Bibtex

@article{e8ee7ff9f47d4fb1ae3818ce0e80c607,
title = "IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies",
abstract = "Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9{\%}. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.",
keywords = "Case-Control Studies, Diabetes Mellitus, Type 2, Genetics, Population, Humans, Interleukin-6, Odds Ratio, Polymorphism, Genetic, Promoter Regions, Genetic, Risk",
author = "Cornelia Huth and Heid, {Iris M} and Caren Vollmert and Christian Gieger and Harald Grallert and Wolford, {Johanna K} and Birgit Langer and Barbara Thorand and Norman Klopp and Hamid, {Yasmin H} and Oluf Pedersen and Torben Hansen and Valeriya Lyssenko and Leif Groop and Christa Meisinger and Angela D{\"o}ring and Hannelore L{\"o}wel and Wolfgang Lieb and Christian Hengstenberg and Wolfgang Rathmann and Stephan Martin and Stephens, {Jeffrey W} and Helen Ireland and Hugh Mather and Miller, {George J} and Stringham, {Heather M} and Michael Boehnke and Jaakko Tuomilehto and Heiner Boeing and Matthias M{\"o}hlig and Joachim Spranger and Andreas Pfeiffer and Ingrid Wernstedt and Anders Niklason and Abel L{\'o}pez-Bermejo and Jos{\'e}-Manuel Fern{\'a}ndez-Real and Hanson, {Robert L} and Luis Gallart and Joan Vendrell and Anastasia Tsiavou and Erifili Hatziagelaki and Humphries, {Steve E} and H-Erich Wichmann and Christian Herder and Thomas Illig",
year = "2006",
doi = "10.2337/db06-0600",
language = "English",
volume = "55",
pages = "2915--21",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "10",

}

RIS

TY - JOUR

T1 - IL6 gene promoter polymorphisms and type 2 diabetes

T2 - joint analysis of individual participants' data from 21 studies

AU - Huth, Cornelia

AU - Heid, Iris M

AU - Vollmert, Caren

AU - Gieger, Christian

AU - Grallert, Harald

AU - Wolford, Johanna K

AU - Langer, Birgit

AU - Thorand, Barbara

AU - Klopp, Norman

AU - Hamid, Yasmin H

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Lyssenko, Valeriya

AU - Groop, Leif

AU - Meisinger, Christa

AU - Döring, Angela

AU - Löwel, Hannelore

AU - Lieb, Wolfgang

AU - Hengstenberg, Christian

AU - Rathmann, Wolfgang

AU - Martin, Stephan

AU - Stephens, Jeffrey W

AU - Ireland, Helen

AU - Mather, Hugh

AU - Miller, George J

AU - Stringham, Heather M

AU - Boehnke, Michael

AU - Tuomilehto, Jaakko

AU - Boeing, Heiner

AU - Möhlig, Matthias

AU - Spranger, Joachim

AU - Pfeiffer, Andreas

AU - Wernstedt, Ingrid

AU - Niklason, Anders

AU - López-Bermejo, Abel

AU - Fernández-Real, José-Manuel

AU - Hanson, Robert L

AU - Gallart, Luis

AU - Vendrell, Joan

AU - Tsiavou, Anastasia

AU - Hatziagelaki, Erifili

AU - Humphries, Steve E

AU - Wichmann, H-Erich

AU - Herder, Christian

AU - Illig, Thomas

PY - 2006

Y1 - 2006

N2 - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

AB - Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 -573G>C and type 2 diabetes. The observed association of the IL6 -174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - Genetics, Population

KW - Humans

KW - Interleukin-6

KW - Odds Ratio

KW - Polymorphism, Genetic

KW - Promoter Regions, Genetic

KW - Risk

U2 - 10.2337/db06-0600

DO - 10.2337/db06-0600

M3 - Journal article

VL - 55

SP - 2915

EP - 2921

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 10

ER -

ID: 38336462