Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins

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Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. / Engelbrechtsen, L; Hansen, T H; Mahendran, Y; Pyl, P; Galijatovic, Ehm Astrid Andersson; Jonsson, A; Gjesing, A; Linneberg, A; Jørgensen, Torben; Hansen, Torben; Vestergaard, H.

In: Scientific Reports, Vol. 7, 43128, 21.02.2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Engelbrechtsen, L, Hansen, TH, Mahendran, Y, Pyl, P, Galijatovic, EAA, Jonsson, A, Gjesing, A, Linneberg, A, Jørgensen, T, Hansen, T & Vestergaard, H 2017, 'Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins', Scientific Reports, vol. 7, 43128. https://doi.org/10.1038/srep43128

APA

Engelbrechtsen, L., Hansen, T. H., Mahendran, Y., Pyl, P., Galijatovic, E. A. A., Jonsson, A., ... Vestergaard, H. (2017). Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. Scientific Reports, 7, [43128]. https://doi.org/10.1038/srep43128

Vancouver

Engelbrechtsen L, Hansen TH, Mahendran Y, Pyl P, Galijatovic EAA, Jonsson A et al. Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. Scientific Reports. 2017 Feb 21;7. 43128. https://doi.org/10.1038/srep43128

Author

Engelbrechtsen, L ; Hansen, T H ; Mahendran, Y ; Pyl, P ; Galijatovic, Ehm Astrid Andersson ; Jonsson, A ; Gjesing, A ; Linneberg, A ; Jørgensen, Torben ; Hansen, Torben ; Vestergaard, H. / Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. In: Scientific Reports. 2017 ; Vol. 7.

Bibtex

@article{c4f4abf4981d4cfaadfc6014d9461b4a,
title = "Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins",
abstract = "The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls). Sixty-two men were recruited based on TCF7L2 genotype, 31 were TT carriers and 31 were age- and BMI-matched CC carriers. All participants consumed a test meal after 12 hours of fasting. Metabolites were measured using proton nuclear magnetic resonance (NMR) spectroscopy. Metabolomic profiling of TCF7L2 carriers were performed for 141 lipid estimates. TT carriers had lower fasting levels of L-VLDL-L (total lipids in large very low density lipoproteins, p = 0.045), L-VLDL-CE (cholesterol esters in large VLDL, p = 0.03), and L-VLDL-C (total cholesterol in large VLDL, p = 0.045) compared to CC carriers. Additionally, TT carriers had lower postprandial levels of total triglycerides (TG) (q = 0.03), VLDL-TG (q = 0.05, including medium, small and extra small, q = 0.048, q = 0.0009, q = 0.04, respectively), HDL-TG (triglycerides in high density lipoproteins q = 0.037) and S-HDL-TG (q = 0.00003). In conclusion, TT carriers show altered postprandial triglyceride response, mainly influencing VLDL and HDL subclasses suggesting a genotype-mediated effect on hepatic lipid regulation.",
keywords = "Journal Article",
author = "L Engelbrechtsen and Hansen, {T H} and Y Mahendran and P Pyl and Galijatovic, {Ehm Astrid Andersson} and A Jonsson and A Gjesing and A Linneberg and Torben J{\o}rgensen and Torben Hansen and H Vestergaard",
year = "2017",
month = "2",
day = "21",
doi = "10.1038/srep43128",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins

AU - Engelbrechtsen, L

AU - Hansen, T H

AU - Mahendran, Y

AU - Pyl, P

AU - Galijatovic, Ehm Astrid Andersson

AU - Jonsson, A

AU - Gjesing, A

AU - Linneberg, A

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Vestergaard, H

PY - 2017/2/21

Y1 - 2017/2/21

N2 - The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls). Sixty-two men were recruited based on TCF7L2 genotype, 31 were TT carriers and 31 were age- and BMI-matched CC carriers. All participants consumed a test meal after 12 hours of fasting. Metabolites were measured using proton nuclear magnetic resonance (NMR) spectroscopy. Metabolomic profiling of TCF7L2 carriers were performed for 141 lipid estimates. TT carriers had lower fasting levels of L-VLDL-L (total lipids in large very low density lipoproteins, p = 0.045), L-VLDL-CE (cholesterol esters in large VLDL, p = 0.03), and L-VLDL-C (total cholesterol in large VLDL, p = 0.045) compared to CC carriers. Additionally, TT carriers had lower postprandial levels of total triglycerides (TG) (q = 0.03), VLDL-TG (q = 0.05, including medium, small and extra small, q = 0.048, q = 0.0009, q = 0.04, respectively), HDL-TG (triglycerides in high density lipoproteins q = 0.037) and S-HDL-TG (q = 0.00003). In conclusion, TT carriers show altered postprandial triglyceride response, mainly influencing VLDL and HDL subclasses suggesting a genotype-mediated effect on hepatic lipid regulation.

AB - The TCF7L2 rs7903146 T-allele shows the strongest association with type 2 diabetes (T2D) among common gene variants. The aim of this study was to assess circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls). Sixty-two men were recruited based on TCF7L2 genotype, 31 were TT carriers and 31 were age- and BMI-matched CC carriers. All participants consumed a test meal after 12 hours of fasting. Metabolites were measured using proton nuclear magnetic resonance (NMR) spectroscopy. Metabolomic profiling of TCF7L2 carriers were performed for 141 lipid estimates. TT carriers had lower fasting levels of L-VLDL-L (total lipids in large very low density lipoproteins, p = 0.045), L-VLDL-CE (cholesterol esters in large VLDL, p = 0.03), and L-VLDL-C (total cholesterol in large VLDL, p = 0.045) compared to CC carriers. Additionally, TT carriers had lower postprandial levels of total triglycerides (TG) (q = 0.03), VLDL-TG (q = 0.05, including medium, small and extra small, q = 0.048, q = 0.0009, q = 0.04, respectively), HDL-TG (triglycerides in high density lipoproteins q = 0.037) and S-HDL-TG (q = 0.00003). In conclusion, TT carriers show altered postprandial triglyceride response, mainly influencing VLDL and HDL subclasses suggesting a genotype-mediated effect on hepatic lipid regulation.

KW - Journal Article

U2 - 10.1038/srep43128

DO - 10.1038/srep43128

M3 - Journal article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 43128

ER -

ID: 174400364