Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

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Grith Møller, Jens Rikardt Andersen, Christian Ritz, Marta P Silvestre, Santiago Navas-Carretero, Elli Jalo, Pia Christensen, Elizabeth M Simpson, Moira A Taylor, J Alfredo Martinez, Ian Macdonald, Nils Swindell, Kelly Mackintosh, Gareth Stratton, Mikael Fogelholm, Thomas Meinert Larsen, Sally D Poppitt, Lars Ove Dragsted, Anne Raben

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year
data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and
kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were
no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.
Original languageEnglish
Article number54
JournalNutrients
Volume54
Number of pages11
ISSN2072-6643
DOIs
Publication statusPublished - 2018

    Research areas

  • The Faculty of Science - Pre-diabetes, Dietary protein, Creatinine clearance, Glomerular filtration rate, Albumin, Urea

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