High tumor uptake of (64)Cu: implications for molecular imaging of tumor characteristics with copper-based PET tracers

Research output: Contribution to journalJournal articleResearchpeer-review

Jesper Tranekjær Jørgensen, Morten Persson, Jacob Madsen, Andreas Kjær

The use of copper-based positron emission tomography (PET) tracers in cancer studies is increasing. However, as copper has previously been found in high concentrations in human tumor tissue in vivo, instability of PET tracers could result in tumor accumulation of non-tracer-bound radioactive copper that may influence PET measurements. Here we determine the degree of (64)Cu uptake in five commonly used human cancer xenograft models in mice. Additionally, we compare copper accumulation in tumor tissue to gene expression of human copper transporter 1 (CTR1).
Original languageEnglish
JournalNuclear Medicine and Biology
Volume40
Issue number3
Pages (from-to)345-50
Number of pages6
ISSN0969-8051
DOIs
Publication statusPublished - Apr 2013

ID: 45845300