High species variation within the repertoire of trace amine receptors

Research output: Contribution to journalConference articleResearch

David E. Gloriam, T K Bjarnadóttir, H B Schiöth, R Fredriksson

Using a variety of search strategies, we obtained the complete or nearly complete repertoire of trace amine receptors from humans, mice, rats, zebrafish, pufferfish, and a number of invertebrates. We found that the number of functional receptors varies from 5 to 50 in each genome, showing that this family of GPCRs has a very dynamic gene repertoire. We show that the previously cloned and characterized GPCRs from insects and mollusks are more closely related to mammalian serotonin, dopamine, and adrenalin receptors than to mammalian TA receptors. This suggests that the ability to bind TAs has arisen independently in different developmental lineages.
Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Number of pages5
ISSN0077-8923
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

    Research areas

  • Amino Acid Sequence, Animals, Genetic Variation, Humans, Molecular Sequence Data, Multigene Family, Phylogeny, Receptors, G-Protein-Coupled, Species Specificity

ID: 45812133