GPCRdb: an information system for G protein-coupled receptors
Research output: Contribution to journal › Journal article › Research › peer-review
- Nucl. Acids Res.-2016-Isberg-D356-64
Final published version, 2 MB, PDF document
Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.
|Journal||Nucleic Acids Research|
|Publication status||Published - 4 Jan 2016|
European Research Council [639125 to D.E.G]; Lundbeck
Foundation [R163-2013-16327 to D.E.G]; Danish Council
for Independent Research [1331-00180 to D.E.G]; Polish
National Science Centre [DEC-2014/12/T/NZ2/00529 to
S.M.]. Funding for open access charge: European Research
Council [639125 to D.E.G].
- Development of new medicine
Number of downloads are based on statistics from Google Scholar and www.ku.dk