Glycine‐modified growth hormone secretagogues identified in seized doping material

Research output: Contribution to journalLetterResearchpeer-review

Paulina Marta Gajda, Niels Bjerre Holm, Lars Jakobsen Hoej, Brian Schou Rasmussen, Petur Weihe Dalsgaard, Lotte Ask Reitzel, Kristian Linnet

A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

Original languageEnglish
JournalDrug Testing and Analysis
Issue number2
Pages (from-to)350-354
Publication statusPublished - Feb 2019

    Research areas

  • doping, growth hormone secretagogues, LC–MS, modified GRF 1–29, Peptide hormones

ID: 203562668