Glycine‐modified growth hormone secretagogues identified in seized doping material
Research output: Contribution to journal › Letter › Research › peer-review
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
|Journal||Drug Testing and Analysis|
|Publication status||Published - Feb 2019|
- doping, growth hormone secretagogues, LC–MS, modified GRF 1–29, Peptide hormones