Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations
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Glucokinase diabetes, also called GCK-MODY or maturity-onset diabetes of the young type 2 (MODY2), is caused by heterozygous mutations in the gene encoding glucokinase (GCK). Objective: The aim of study was to investigate the current prevalence of GCK mutations in a large cohort of Czech patients with typical clinical appearance of GCK-MODY. In addition, we reanalyzed the negative results obtained previously by screening using the denaturing high-performance liquid chromatography (dHPLC).
|Journal||Pediatric Diabetes Online|
|Number of pages||7|
|Publication status||Published - 1 Dec 2010|
- Adolescent, Child, Chromatography, High Pressure Liquid, Czech Republic, Diabetes Mellitus, Type 2, Glucokinase, Humans, Mutation, Prevalence, Protein Denaturation, Young Adult